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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 22
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Short Communications

The chemical profile and biological activity of different extracts of Sapindus mukorossi Gaertn. against Cutibacterium acnes

Min-Ping Weia State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
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Jin-Dan Qiua State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
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Lu Lia State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
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Yun-Fei Xiea State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
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Ya-Hui Guoa State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
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Hang Yua State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
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Yu-Liang Chenga State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
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He Qiana State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaView further author information
&
Wei-Rong Yaoa State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu Province, China;c Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu Province, ChinaCorrespondence[email protected]
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Pages 4740-4745 | Received 07 Sep 2019, Accepted 04 Jan 2020, Published online: 29 Jan 2020
 
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Abstract

This study evaluated the antibacterial activities of different extracts of Sapindus mukorossi Gaertn. (S. mukorossi) on Cutibacterium acnes (C. acnes). The extract solvent and procedure were screened, based on the yield of saponins and minimum inhibitory concentration (MIC). The results showed that the optimized product, fermentation and ethyl acetate extract by adding isoamyl alcohol from water extract of S. mukorossi (SWFEAI), had the highest yield of saponins (7.83 ± 0.26%) and the best antibacterial activity (MIC = 0.125 mg/mL) on C. acnes. The destroyed bacterial cell membrane and wall were observed by transmission electron microscopy, which then resulted in cell lysis and death. Furthermore, 20 compounds of SWFEAI were detected, among which oleanane-type triterpenoid saponins with molecular weights of 734, 750, 882, 924 and 966 were speculated to contribute to the antibacterial activities of SWFEAI. The results showed that SWFEAI could be a natural anti-acne agent.

Graphical Abstract

Disclosure statement

There is no conflict of interest of any authors in relation to the submission.

Additional information

Funding

The work described in this article was supported by the National First-class Discipline Program of Food Science and Technology (JUFSTR20180509).

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