Antifungal fatty acid derivatives against Penicillium italicum from the deep-sea fungus Aspergillus terreus SCSIO 41202

Abstract

The present work reports the bioassay-guided isolation of four bioactive fatty acid derivatives involving a new butenolide, namely sinulolide I (1) together with three known metabolites (2–4) from the deep-sea sediment derived fungus Aspergillus terreus SCSIO 41202. The chemical structure of compound 1 was elucidated based on extensive spectroscopic methods (1D/2D NMR and HR-ESI-MS), optical rotation and circular dichroism analyses, while the structures of the known compounds (2–4) were established by comparison of NMR spectral data with those reported in literature. All of these four compounds (1–4) exhibited significant antifungal activity against citrus postharvest pathogen Penicillium italicum (MICs around 0.031–0.125 mg/mL).

Graphical Abstract

Keywords:

• Aspergillus terreus
• antifungal
• butenolide
• Penicillium italicum
• fatty acid

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research work was financially supported by the National Natural Science Foundation of China (Nos. 3186 , 41506156), Natural Science Foundation of Jiangxi Province (No. 20171BCB24011), Research Foundation from Department of Education of Jiangxi Province (Nos. GJJ160925, GJJ170847), Innovation program for postgraduate student (YCX18B008) and Key R&D project of Ganzhou municipal (No. 2017179).