https://orcid.org/0000-0003-1626-1240
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Abstract
One new long-chain ester derivative of trans-ferulic acid 1 and one natural tirucallane-type triterpenoid 2, together with forty known compounds (3-42), were isolated from the barks of Melia azedarach. Their structures were established on the basis of spectroscopic data interpretation. Compounds 7, 9, 10, 12, 13 showed significant inhibitory activities against PTP1B with IC50 values of 13.82 ± 1.29 μM, 13.29 ± 2.26 μM, 20.27 ± 0.52 μM, 24.36 ± 1.25 μM, 15.23 ± 0.6 μM, respectively.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China under Grant 81360477; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University under Grant CMEMR2018-B03; and National Training Program of Innovation and Entrepreneurship for Undergraduates under Grant 201810601015. The PTP1B inhibitory assay was carried out by the National Centre for Drug Screening, Shanghai.