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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 23
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Short Communications

Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora

Allan Patrick G. Macabeoa Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, PhilippinesCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-7972-106XView further author information
ORCID Icon,
Angeli Izza G. Floresa Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, PhilippinesView further author information
,
Rey Arturo T. Fernandeza Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, PhilippinesView further author information
,
Simon Buddeb Institut fur Organische Chemie, Universität Regensburg, Regensburg, GermanyView further author information
,
Christian Faderlb Institut fur Organische Chemie, Universität Regensburg, Regensburg, GermanyView further author information
,
Hans-Martin Dahsec Leibniz-Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute (HKI), Jena, GermanyView further author information
&
Scott G. Franzblaud Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USAView further author information
 show all
Pages 5229-5232 | Received 12 Oct 2019, Accepted 05 Mar 2020, Published online: 23 Mar 2020
 
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Abstract

Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC90 value of 51.2 μM and antiproliferative or cytotoxic activity against human myeloid leukaemia (K-562) and HeLa cells with IC50 values of 2.3 and 18.3 μM, respectively.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was supported by International Foundation for Science [No. 31672069].

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