https://orcid.org/0000-0001-8615-4710
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Abstract
Two new 19-hydroxy bufadienolides, named bufohydrolide A (1) and bufohydrolide B (2), and four known analogs (3-6) were isolated from the aqueous extracts of the skins of Bufo melanosticus. Their structures were established by spectral data analyses, such as UV, IR, 1 D/2D NMR and mass spectra. Compounds 1-6 were evaluated for their cytotoxic activity against SMMC-7721, HT-29 and A549 cells. Noteworthily, all six isolates exhibited various levels of anti-proliferative activities with IC50 values ranging from 0.02 ± 0.0002 to 25 ± 0.5 μM.
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Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This work was supported by Natural Science Foundation of China (81660611), Youth Science &Technology Personal Growth Project of the Educational Department of Guizhou Province (KY [2018] 230),The Foundation of Zunyi Medical University [F-988, F-972, 20173828], Science & Technology Plan of Zunyi (2018 [18]), Guizhou Provincial Science & Technology Program (QKH [2017]5733-059, QKH [2019]1346), Science & Technology Talent Support Project of the Educational Department of Guizhou Province (KY [2018] 055).