Goodyschle A, a new butenolide with significant BchE inhibitory activity from Goodyera schlechtendaliana

Abstract

Goodyschle A (1), a new butenolide, was isolated from the whole grass of Goodyera schlechtendaliana, an orchidaceous edible medicinal plant. The structure of the new compound was elucidated by 1 D and 2 D NMR experiments in addition to HRESIMS analyses. Compound 1 was evaluated for its bioactivities including cytotoxic activity against human gastric cancer (SGC-7901) and human hepatocellular carcinoma (HepG2) cell lines, inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and DPPH radical scavenging activity. As a result, compound 1 showed potent BChE inhibitory activity (IC₅₀ value = 6.88 ± 1.63 μM), moderate DPPH radical scavenging activity (IC₅₀ value = 16.25 ± 0.21 μM), and slight AChE inhibitory and cytotoxic activities. These findings suggest that compound 1 is worthy for further investigations in terms of its selective BChE inhibitory activity.

Graphical Abstract

Keywords:

• Goodyera schlechtendaliana
• goodyshle A
• butenolide
• selective BchE inhibitory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research work was supported by Qinglan Project of Yangzhou University (20180210) and University Student Academic Science and Technology Innovation Fund of Yangzhou University (201811117088X).