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Abstract
A new (naphthalenyl)methyl acetate, (1,4,5-trimethoxynaphthalen-2-yl)methyl acetate (1) and (±)-4,5-dihydroxy-2-methyltetralone (2) were isolated together with five lupane triterpenes (3–7), naphthoquinone derivatives (8–13), coumarins (14 and 15) and a vanillic acid (16) from the stems of Diospyros ehretioides. Their structures were established through spectroscopic analysis, IR, 1D and 2D NMR. Both 1 and 2 displayed significant cytotoxicity against three cancer cell lines including HeLa, HCT116 and MCF-7, with IC50 values in the range of 5.05–15.90 µg/mL, while 16 exhibited moderate cytotoxicity against HeLa and HCT116 cell lines and was not toxic to Vero cells.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the Centre of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research and Innovation (Implementation Unit-IU, Khon Kaen University) and Natural Products Research Unit, Department of Chemistry, Faculty of Science, Khon Kaen University.