Cytotoxicity of acylphloroglucinol derivatives from the fruits of Horsfieldia irya

Abstract

Four new acylphloroglucinol derivatives 1, 3, 5 and 13 were isolated from the fruits of Horsfieldia irya, and in addition, thirteen known compounds were also discovered. All compounds were evaluated for cytotoxicity against HeLa and HCT116 cell lines, as well as normal cells (Vero cells). Compound 13 showed cytotoxicity against HeLa and HCT116 cell lines with IC₅₀ values of 4.53 ± 0.05 and 4.53 ± 0.16 μg/mL, respectively, and showed less activity against normal cells (IC₅₀ = 13.38 ± 0.75 μg/mL). Compound 13 may be useful for the development of anticancer agents. It was found that decanoyl side chain may be necessary for the cytotoxicity. The chemical structures of all isolated compounds were elucidated using spectroscopic methods including 1 D-NMR, 2 D-NMR, MS and IR data.

Graphical Abstract

Keywords:

• Horsfieldia irya
• acylphloroglucinol
• flavan-acylphloroglucinol
• HeLa cells
• HCT116 cells

Acknowledgements

We are indebted to The Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research and Innovation (Implementation Unit, Khon Kaen), Thailand.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was partially supported by the Thailand Research Fund and Khon Kaen University [RSA6280050]. The Post-Doctoral Training Program from Research Affairs and Graduate School, Khon Kaen University for Jittra Suthiwong [Grant no. 590012] and Thurdpong Sribuhom are acknowledged [Grant no. 591471].