Hyperprzeone A, a new benzophenone with cytotoxicity from Hypericum przewalskii Maxim

Abstract

The phytochemical investigation on the whole plant of Hypericum przewalskii yielded a new benzophenone, hyperprzeone A (1) together with 20 known compounds (2–21). The structure of compound 1 was elucidated by detailed 1D and 2D NMR spectroscopic techniques as well as MS evidence. Some compounds displayed selective cytotoxic activity against six human tumour cell lines (SH-SY5Y, MDA-MB-231, SiHa, SMMC-7721, NCI-H460 and A375). Hyperprzeone A (1) showed moderate cytotoxicity against SH-SY5Y cell with the IC₅₀ value as 25.54 μM, and further flow cytometry analysis revealed that hyperprzeone A (1) caused SH-SY5Y cell apoptosis in a dose-dependent manner by blocked the cell cycle at S phase.

Graphical Abstract

Keywords:

• Hypericum przewalskii
• benzophenone
• cytotoxicity
• apoptosis
• cell cycle

Acknowledgements

The authors thank the Center of Scientific Research of Anhui Medical University for kind help in our experiments.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The work was supported by the National Natural Science Foundation of China (31670353).