Angiotensin-converting enzyme inhibitors from Salvia elegans Vahl

Abstract

Phytochemical research of the acetate and methanol extracts of the aerial parts (flowers, leaves and stems) of Salvia elegans allowed to obtain seventeen known compounds (1–17): three of them (4, 5, 14), had already been described for this species, while the others (1–3, 6–13, 15–17) are described for the first time for S. elegans. All isolated compounds were characterized using spectroscopic techniques and mass spectrometry and were evaluated in the Angiotensin I-converting enzyme (ACE) inhibition model, where the phenolic compounds (13, 14 and 15) had the same inhibitory effect as lisinopril at 0.02 mg/mL. The terpenes showed a moderate inhibitory capacity at a concentration of 0.2 mg/mL.

Graphical Abstract

Keywords:

• Salvia elegans Vahl
• Angiotensin-converting enzyme inhibitor
• phenolic compounds
• terpenes

Acknowledgments

This research was supported by grant from IMSS-Mexico (99187268) and CONACYT-Mexico Grant (589809) for Master Studies of Ana Silvia Gutiérrez-Román. Technical spectroscopic and spectrometric support from UAM-Xoc.

Disclosure statement

The authors declare that they have no conflict of interests related with the present investigation.

Additional information

Funding

This research was funded by Instituto Mexicano del Seguro Social Grant number: FIS/IMSS/PROT/PRIO/14/029 and Secretaría de Investigación y Posgrado-IPN Grant number: 1776-20170469.