https://orcid.org/0000-0002-0779-4013
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Abstract
A chemical investigation of Sophora flavescens Ait. identified 6 compounds. On the basis of spectroscopic data, they were determined to be flavonoids and their analogues, among which were two previously undescribed compounds, sophoflavanone G (1) and sophoflavanone H (2). The inhibitory effects of new compounds against five human tumour cell lines were evaluated in vitro by MTT assays, which revealed potential inhibitory effects with IC50 values < 20 mM, in particular, compound 1 has shown significant cytotoxicity for several tumour cells with IC50 values around 20 mM, which was similar to cisplatin and potential to be used as tumour drugs.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the National Key R&D Program of China (2017YFC1701200) and the National Natural Science Foundation of China (No. 81374061, 81903789); the Program for Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University.
