https://orcid.org/0000-0002-4989-9315
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Abstract
Bioactivity-guided fractionation of the CHCl3-soluble extract of the roots of Paramignya trimera was carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC50 values of 0.43 and 0.26 µM, respectively. The N-methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity.
Graphical Abstract
Supplementary material
Copies of spectroscopic data (Figure S2–S7) for compounds 1 and 2.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This research was funded by Viet Nam National University Ho Chi Minh City (VNU-HCM) under grant number 562-2018-18-04, to N.T. Nguyen.
