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Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 1
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Research Articles

Two new nor-lignans from Selaginella pulvinata (Hook. & Grev.) Maxim and their antihyperglycemic activities

Hua-Wei Lva College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
,
Yu-Xia Lia College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
,
Meng Luoa College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
,
Jia-Meng Qia College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
,
Ze-Fei Fub Production center, Zhejiang Yuanlijian Pharmaceutical Co., Ltd, Jiande, P.R. ChinaView further author information
,
Hong-Jian Zhangc Center for Medicinal Resources Research, Key Laboratory of Research and Development of Chinese Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, P.R. ChinaView further author information
,
Yuan-Qiang Guod State Key Laboratory  of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, P.R. China View further author information
,
Chu Chua College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. ChinaView further author information
,
Han-Bing Lia College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. ChinaCorrespondence[email protected]
View further author information
&
Ji-Zhong Yana College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. ChinaCorrespondence[email protected]
View further author information
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Pages 279-286 | Received 09 Mar 2020, Accepted 23 May 2020, Published online: 22 Jun 2020
 
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Abstract

Two new nor-lignans, pulvin A (1) and moellenoside C (2), along with two known compounds (3–4) were isolated from the whole plant of Selaginella pulvinate (Hook. & Grev.) Maxim. The structures of the new compounds were established on the basis of spectroscopic data and acid hydrolysis. All the isolates were investigated for their antihyperglycemic activities in 3T3-L1 adipocytes. The results showed that compounds 1 and 2 promoted the glucose consumption prominently in 3T3-L1 adipocytes in a dose-response manner. Compound 1 and 2 induced 1.14–1.73 folds and 1.03–1.55 folds changes relative to the basal level, respectively, in the concentration range of 12.5 μM to 50 μM.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National Natural Science Foundation of China under Grant NO.81603255.

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