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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 23
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Research Articles

A new cytotoxic cardenolide from the roots of Calotropis gigantea

Mai T. T. Nguyena Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam;b Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam;c Vietnam National University, Ho Chi Minh City, VietnamView further author information
,
Khang D. H. Nguyena Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam;c Vietnam National University, Ho Chi Minh City, VietnamView further author information
,
Phu H. Danga Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam;c Vietnam National University, Ho Chi Minh City, VietnamORCID Iconhttps://orcid.org/0000-0002-4989-9315View further author information
ORCID Icon,
Hai X. Nguyena Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam;c Vietnam National University, Ho Chi Minh City, VietnamORCID Iconhttps://orcid.org/0000-0001-8447-8367View further author information
ORCID Icon,
Suresh Awaled Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, JapanCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-5299-193XView further author information
ORCID Icon &
Nhan T. Nguyena Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam;b Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam;c Vietnam National University, Ho Chi Minh City, VietnamCorrespondence[email protected] [email protected]
View further author information
Pages 5096-5101 | Received 01 Apr 2020, Accepted 30 May 2020, Published online: 22 Jun 2020
 
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Abstract

Bioactivity-guided isolation of the CHCl3-soluble fraction of the roots of Calotropis gigantea was carried out to obtain a new cardenolide glycoside, caloside G. Its absolute structure was elucidated based on NMR and ECD spectroscopic data interpretation. Caloside G showed noteworthy cytotoxicity against the PANC-1 human pancreatic and HeLa human cervical carcinoma cell lines, with the submicromolar IC50 values of 0.038 and 0.09 µM, respectively.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by Vietnam National University, Ho Chi Minh City (VNU-HCM), under grant number B2019-18-04 to MTTN.

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A new cytotoxic cardenolide from the roots of Calotropis gigantea
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