Natural Product Research

Formerly Natural Product Letters

Volume 35, 2021 - Issue 23

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Research Articles

Nematicidal activity of oleanolic acid derivatives on Meloidogyne incognita

Zareena Kirana H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Nabila Hassanb Department of Chemistry, NED University of Engineering & Technology, Karachi, Pakistan

Anjum Ayubb Department of Chemistry, NED University of Engineering & Technology, Karachi, Pakistan

Sara Saraa H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Zarina Banoa H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Sabira Beguma H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PakistanCorrespondence[email protected]

Bina S. Siddiquia H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Shahina Fayyazc National Nematological Research Center, University of Karachi, Karachi, Pakistan

Erum Iqbalc National Nematological Research Center, University of Karachi, Karachi, Pakistan

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Abstract

In this study, oleanolic acid and its derivatives were studied for their invivo nematicidal activity against root-knot nematode (RKN) Meloidogyne incognita. A series of C-28-oleanolates including five new (5, 7–10) and seven known (1–4, 6, 11, 12) compounds were synthesised and their nematicidal activity was determined and compared with the standard nematicide furadan for the first time. The structures of the compounds were elucidated through ¹H NMR, ¹³C NMR and EIMS. Compounds 4, 5, 7, 8 and 10 showed ∼ 90% inhibition of RKN at 0.125% concentration after 72 h showing their potential use in nematicidal control.

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Nematicidal activity of oleanolic acid derivatives on Meloidogyne incognita

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Nematicidal activity of oleanolic acid derivatives on Meloidogyne incognita

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