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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
293
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Short Communications

Virtual screening of active compounds from jasminum lanceolarium and potential targets against primary dysmenorrhea based on network pharmacology

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Pages 5853-5856 | Received 18 May 2020, Accepted 03 Jul 2020, Published online: 22 Jul 2020
 

Abstract

In present study, multi-target and multi-pathway mechanisms of Jasminum lanceolarium Roxb (JL) on primary dysmenorrhea (PDM) treatment were predicted by the approach of network pharmacology and molecular docking, leading to the obtaining of 22 predicted targets for 69 compounds in JL. The Compound-Target analysis displayed intimate association among targets and compounds. Meanwhile, the Compound-Target-Target revealed PTGS2, OPRD1 and NOS3 were the key targets with intensive interaction. The Compound-Target-Pathway network indicated these pathways were closely related to hormone regulation, central analgesia, spasmolysis and inflammation. The anti-inflammation pathways might be the key mechanism of JL for the treatment of PDM based on KEGG pathway enrichment analysis and pharmacological experiment, and 10-hydroxyoleoside dimethyl ester might be a promising leading compound due to its good molecular docking scores and previous experimental evaluation.

Graphical Abstract

Disclosure statement

The authors declare that there are no conflicts of interest.

Additional information

Funding

This work is supported by the National Natural Science Foundation of China (Grant No. 81573694), and the project is sponsored by “Liaoning BaiQianWan Talents Program”.

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