https://orcid.org/0000-0002-1060-2326
![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
New cycloartane-type triterpene 23 R/S-3β-hydroxycycloart-24-ene-23-methyl ether 1a,b (as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts of Euphorbia dendroides L. (Euphorbiaceae). The known compounds (2–11) were identified using 1 D & 2 D-NMR spectra and by comparison with data reported in the literature as well as using GC-MS for the isolated fatty acids. The new compound 1 (a,b) was elucidated by comprehensive 1 D & 2 D NMR experiments as well as LR & HR-FAB-MS. In addition, the isolated cycloartane-type triterpenoids have been tested for in vitro cytotoxicity against different cell lines. The new compound 1 (a,b) exhibited good to weak selective cytotoxic activities against HepG2, Huh-7, KLM-1, 1321N1 and HeLa cell lines with IC50 values of 20.67 ± 0.72, 16.24 ± 0.53, 22.59 ± 0.94, 25.99 ± 0.31 and 40.50 ± 3.14 μM, respectively.
Graphical Abstract
Acknowledgements
The Egyptian Ministry of Higher Education and Scientific Research is acknowledged for the Post-doctoral fellowship support to Ahmed R. Hassan. We would like to express our gratitude to Prof. Tomofumi Miyamoto, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan, for carrying out the optical rotation measurement. We would like also to thank Ms. Noriko Yazawa for measurement of Bruker DRX 600 NMR spectrometer and Mr. Toshio Nishi, Evaluation Center of Materials Properties and Function, IMCE, Kyushu University for measurement of LR- and HR-FAB-MS.
Supplementary material
The experimental section, 1D- & 2D-NMR and positive LR- & HR-FAB-MS spectra for the new compound 1(a,b) can be found in the online version of this article.
Disclosure statement
No potential conflict of interest was reported by the authors.
