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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Short Communications

Resorcinol derivatives with α-glucosidase inhibitory activities from Syzygium samarangense

, , , , , & show all
Pages 5948-5953 | Received 03 Jun 2020, Accepted 26 Jul 2020, Published online: 13 Aug 2020
 

Abstract

Nine resorcinol derivatives including two new ones, 5-[(8Z,11Z,14Z)-nonadeca−8,11,14-trienyl] resorcinol (1) and 5-[(8Z,11Z,14E)-heptadeca-8,11,14-trienyl] resorcinol (2), were isolated from the leaves of Syzygium samarangense. The new structures were elucidated by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Among them, compounds 3, 4, 6 and 7 exhibited significant α-glucosidase inhibitory activities with IC50 of 3.16, 3.16, 2.34 and 0.99 µM, respectively. This finding provides evidence that resorcinol derivatives with long aliphatic chain function as new promising antidiabetic alternatives.

Disclosure statement

No conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 31560098 and 81522044), the National Key R&D Program of China (2018YFA0900600) and Mid-aged and Young Academic and Technical Leader Raising Foundation of Yunnan Province (No. 2010CI040), China.

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