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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Research Articles

Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl.

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Pages 5604-5611 | Received 23 May 2020, Accepted 29 Jul 2020, Published online: 13 Aug 2020
 

Abstract

A new xanthone, mboudiexanthone (1), together with five known compounds, euxanthone (2), isogarcinol (3), garcinol (4), betulinic acid (5) and zeorin (6) were isolated from the leaves of Garcinia nobilis Engl. The structures were determined by 1D and 2D NMR techniques and X-ray diffraction for 6. The in vitro antiproliferative properties of isolated compounds were evaluated against the human breast cancer cell line MCF-7. All compounds showed an antiproliferative activity with an IC50 value down to ∼11 µM for isogarcinol.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

HF acknowledges the German Academic Exchange Service (DAAD, Letter of Award-ST32-PKZ: 91691026-09/08/2018) for the fellowship at Bielefeld University (Germany) and the financial support from ARES-CCD (Belgium). Grateful acknowledgment is also made to the Swiss National Foundation for providing financial support to JPD through the project n° IZSEZO_180383/1 for the biological part of this work at the Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva.

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