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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Short Communications

Anti-epileptic potential, metabolic profiling and in silico studies of the aqueous fraction from Ocimum menthiifolium benth, family Lamiaceae

, , , , , , & show all
Pages 5972-5976 | Received 04 Apr 2020, Accepted 03 Aug 2020, Published online: 18 Aug 2020
 

Abstract

The current study aimed to investigate the anti-epileptic potential of the ethanol extract and its different fractions from the Lamiaceous plant, Ocimum menthiifolium. The results revealed that the aqueous fraction with the latest onset of myoclonic convulsions (1095 ± 45**** s) was the most biologically active one. This was followed by LC-HR-MS-coupled metabolic profiling which led to dereplication of 8 compounds from that fraction. A molecular docking study was performed on the dereplicated compounds to discover the main responsible ones for the activity. The results highlighted Apigenin-7,4'-di-O-glucoside as the top scoring ligand with a possible mechanism of action involving the modulation of the voltage-gated sodium channel.

Acknowledgement

We would like to thank Markus Krischke and Martin Müller (University of Würzburg) for LC-MS measurment.

Disclosure statement

No potential conflict of interest was reported by the authors.

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