Two new glycosides, farnesyl pentaglycoside and oleanane triglycoside from Lepisanthes rubiginosa, a mangrove plant collected from Thua Thien-Hue province, Vietnam

Abstract

Phytochemical investigation of the leaves of Lepisanthes rubiginosa led to the isolation of two new glycosides, lepisantheside A (1) and lepisantheside B (2), together with two known compounds acutoside A (3) and 3-O-[β-D-xylopyranosyl-(1→3)-β-D-glucopyranosyl-]-oleanolic acid (4). Their structures were elucidated by means of spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds 1–4 against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated. Compound 4 exhibited significant activity with IC₅₀ values of 9.57, 6.66, 6.97 and 18.32 µM, respectively, in comparison with the postive control ellipticine.

Graphical Abstract

Keywords:

• Lepisanthes rubiginosa
• mangrove plant
• Lepisantheside A
• Lepisantheside B
• farnesyl glycoside
• oleanane glycoside
• cytotoxic activity

Acknowledgments

The authors are grateful to Vietnam Academy of Science and Technology (VAST) for financial support (Project Nr.: VAST04-02/18-19), Dr. Do Xuan Cam (Hue University) for the identification of plant sample.

Disclosure statement

No potential conflict of interest was reported by the authors.