Natural Product Research

Formerly Natural Product Letters

Volume 35, 2021 - Issue 24

170

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Research Articles

Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

Tjitjik Srie TjahjandarieNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaCorrespondence[email protected]
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Mulyadi TanjungNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information

Ratih Dewi SaputriNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information

Devina Oktari RahayuNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information

Alfiah Nur Irza GunawanNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information

Muhammad Fajar AldinNatural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, IndonesiaView further author information

Abstract

Two new 2-arylbenzofurans, sesbagrandiflorain D (1) and E (2) along with two known 2-arylbenzofurans, spinosan A (3) and spinosan B (4) were isolated from the stem bark of Sesbania grandiflora L. The structure of two new compounds established by HRESIMS, 1 D NMR (¹H, ¹³C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (1-4) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr). Compound 1 showed very high activity against MCF-7 and WiDr with an IC₅₀ value of 0.06 and 0.60 μg/mL, respectively.

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Supplementary material

HRESIMS, 1 D, and 2 D NMR spectra reported in the supplementary materials as Figure S1–S12 and related to the following articles are available online.

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The authors declare no conflict of interest.

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Funding

This research supported by Fundamental Research Grant (Penelitian Dasar), 2019, Universitas Airlangga, Surabaya.

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Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

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Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell

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