Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice

Abstract

This work aimed to investigate the hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis. The main compounds in licorice total flavonoids (LTF) were isolated from Glycyrrhiza uralensis and their total content in LTF were more than 60%. Hepatoprotective effects of LTF were investigated in three kinds of hepatic injury mice model induced by high-fat emulsion, Chinese liquor and tetrachloromethane. Serum ALT, AST and ALP levels and hepatic MDA, TG, cholesterol, and hydroxyproline of hepatic injury mice were reduced by LTF. Simultaneously, hepatic SOD and glutathione were increased by LTF. These results suggested that LTF can repair liver tissue and reduce hepatic injury via alleviating inflammation, improving antioxidant enzyme activity and reducing oxidative stress in liver tissue and it may be a valuable natural source of hepatoprotective activity.

Graphical Abstract

Keywords:

• Alcoholic liver
• flavonoid
• Glycyrrhiza
• hepatic fibrosis
• liver injury
• NAFLD

Acknowledgements

All data and materials are available, and there is no conflict of interest in the research. This study was supported by the Science and Technology Pillar program fund of Gansu Province (1204FKC151). These experiments were designed by Jingman Ni and Sanhu Gou. Flavonoid monomers were separated by Sanhu Gou and Xu Ouyang. Hepatoprotective activity experiments were completed by Sanhu Gou, Miao He, and Beibei Li. Data was collated and the manuscript was written by Sanhu Gou, Chao Zhong and Ning yi Zhu.

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by the Key Research Development Programs of the Provincial Science & Technology Research Projects of Gansu Province (17YF1FA125).