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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 24
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Research Articles

Manniindole, an indole derivative from the roots of Anonidium mannii and combined antischistosomal and enzymatic activities

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Pages 5665-5673 | Received 17 Jul 2020, Accepted 31 Aug 2020, Published online: 28 Sep 2020
 

Abstract

A new alkaloid, manniindole 1, together with four known compounds: aristolactam AII 2, aristolactam BII 3, piperolactam D 4 and polycarpol 5 were isolated from the crude extract EtOH-H2O (8:2) of the roots of Anonidium mannii by chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison of their spectral data with those reported in the literature. For the first time, the crude extract and those isolated compounds were evaluated for their anti-schistosomal activity against Schistosoma mansoni and for cytotoxicity activity against Huh7 and A549 cells. Furthermore, they were also tested in vitro on the recent characterized Schistosoma mansoni NAD+ catabolizing enzyme (SmNACE) for their impact on this enzyme which is localized on the outer surface of the adult parasite. Compound 2 displayed quite good worm killing capability, while 4 showed significant inhibition of SmNACE.

Acknowledgments

The authors are thankful to AUF for providing a fellowship to J L T M.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethic statement

The laboratory where the experiments were done has permission A66040 from «Ministère de l’Enseignement supérieur de la Recherche et de l’Innovation (France)» for animal experimentation. Experimenters possess the certificate for animal experimentation (authorization 007083, decree 87-848 and 2012201-0008). Housing, breeding and animal care followed the national and European ethical requirements.

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