Abstract
Two new polyphenols, talaversatilis A (1) and B (2), together with fifteen known compounds (3–17) were isolated from the extract of the culture broth of a soft coral-derived fungus Talaromyces sp. SCSIO 041201. The structures of these compounds were elucidated by the extensive analyses of spectroscopic data and by comparison with the reported literature. Antifouling and antibacterial activities of all purified compounds were tested and evaluated. Compounds 5 and 6 showed antifouling activity towards Bugula neritina larva, with LC50 values of 3.86 μg/mL and 3.05 μg/mL, respectively. Compounds 7, 8, 10 and 13 exhibited significant antibacterial activities against E. coli, MRSA, S. aureus and E. faecalis, with MIC values ranging from 0.45 to 15.6 μg/mL.
Graphical Abstract
Supplementary material
Supplementary material relating to this article is available online, alongside Table S1 and Figures S1–S19.
Acknowledgements
We are grateful to Dr. Z. Xiao, A. Sun, C. Li, and Y. Zhang in the analytical facilities at SCSIO for recording spectroscopic data.
Disclosure statement
No potential conflict of interest was reported by the authors.