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Abstract
Effect of Moringa oleifera, an age-old ingredient of Indian ayurvedic and traditional medicine, was tested for its effect on age related antioxidant activity in Wistar albino rats of three age groups (6, 12 and 18 months old). Aqueous extract of M. oleifera leaves (MOAE) was administered orally at a dosage of 200 mg/kg body weight for a period of 30 days. MOAE treatment showed significant reduction in lipid peroxidation and lipofuscin pigmentation along with elevated serotonin and antioxidant enzymes in the brains of treated groups of aged rats. LC-MS-MS analysis revealed blood brain barrier permeable secondary metabolites viz., 9,9-bianthracene, 4-Methoxycinnamic acid, Cinnamic acid, (E)-p-coumaric acid pyrogallol and ostruthin from the extract. 9,9-bianthracene and ostruthin showed better binding affinity to Keap-1 and SERT in silico. The present result suggests the protective efficacy of M oleifera against age related oxidative stress in brain.
Graphical Abstract
Acknowledgements
The correspondent author thank UGC for the financial assistance in the form of Junior Research Fellowship (JRF). The authors also thank Dr. Athira K.K, Dr. Haima J.S, Dr. Dhanusha G and Dr. Dhabolkar Akshay RajKumar for their help; the College of Veterinary and Animal Sciences, Kerala, India for providing the facilities and IIT Bombay (SAIF Lab) for providing the LCMS Orbitrap service.
Disclosure statement
No potential conflict of interest was reported by the authors.