Saffloflavone, a new flavonoid from the flowers of Carthamus tinctorius L. and its cardioprotective activity

Abstract

A new flavonoid, saffloflavone , along with six known compounds, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, quercetin-3-O-β-d-glucoside, quercetin-7-O-β-d-glucoside, luteolin-7-O-β-d-glucoside and kaempferol 3-O-β-d-glucoside were isolated from the flowers of Carthamus tinctorius L. All the structures were determined by interpretation of their spectroscopic data. The cardioprotective effects of all the isolates against oxidative stress of H9c2 cells induced by H₂O₂ were investigated. The results showed that compounds 4–6 exhibited protective effects against of H9c2 cells injury induced by H₂O_2.

Graphical Abstract

Keywords:

• Asteracea
• Carthamus tinctorius L
• flavonoids
• cardioprotective activity

Disclosure statement

The authors have declared that there is no conflict of interest.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by the Central Government Guide Local Science and Technology Development Funds ([2016]149). ¹H NMR: proton nuclear magnetic resonance ¹³C NMR: carbon nuclear magnetic resonance HSQC: ¹H detected heteronuclear single quantum coherence HMBC: ¹H detected heteronuclear multiple bond correlation NMR: nuclear magnetic resonance MS: mass spectrometry IR: infrared spectrum UV: ultraviolet absorption spectrum MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide DMSO: dimethyl sulfoxide