New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity

Abstract

Two new piericidins A5 (1) and G1 (2), a previously synthesized piericidin G2 (3), and two known piericidins A1 (4) and A2 (5) were isolated from the marine-derived Streptomyces sp. SCSIO 40063. The structures of 1-5 were elucidated by HRESIMS, 1 D, 2 D NMR data analyses and comparisons with the known compounds. Compound 2 showed moderate cytotoxicities against four human tumor cell lines SF-268, MCF-7, HepG2 and A549 with IC₅₀ values between 10.0 and 12.7 μM.

Graphical Abstract

Keywords:

• Piericidin A5
• piericidin G1
• α-pyridone derivative
• marine Streptomyces
• cytotoxic activity

Acknowledgements

We appreciate Dr. Yuchan Chen and Prof. Weimin Zhang of Guangdong Institute of Microbiology for cytotoxic activity assay. We are grateful to Zhihui Xiao, Xiaohong Zheng, Aijun Sun, Xuan Ma and Yun Zhang in the analytical facilities of SCSIO.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Key-Area Research and Development Program of Guangdong Province under Grant 2020B1111030005; the Chinese Academy of Sciences under Grant XDA13020302 and QYZDJ-SSW-DQC004; the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) under Grant GML2019ZD0406; and the Special Support Program for Training High-Level Talents in Guangdong under Grant 2019TQ05H299.