Two new physalins from Physalis alkekengi L. var. franchetii (Mast.) Makino

Abstract

Two new physalins, 7α-hydroxy-5-deoxy-4-dehydrophysalin IX (1) and 5-deoxy-4-dehydrophysalin IX (2), together with six known compounds, luteolin (3), luteolin-7-O-glucoside (4), neoechinulin A (5), 3-(4-hydroxy-3-methoxyphenyl)-N-(4-methylphenyl)-2-propenamide (6), physalin D (7) and blumenol A (8) were isolated from Physalis alkekengi L. var. franchetii (Mast.) Makino. Their structures were elucidated by NMR spectroscopic analysis, HR-ESI-MS, X-ray crystallographic data analysis and comparison with the known compounds. Among them, compounds 5 and 6 were isolated from the genus Physalis for the first time. Compound 1 exhibited weak NAD(P)H: quinone reductase (QR) inducing activity.

Graphical Abstract

Keywords:

• Physalins
• Physalis alkekengi L. var. franchetii (Mast.) Makino
• 5-deoxy-4-dehydrophysalin IX
• 7α-hydroxy-5-deoxy-4-dehydrophysalin IX

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by National Natural Science Foundation of China (81673558), the fourth national survey on Chinese material medica resources (No.2019-0994), and Qilu Young Scholars Program of Shandong University.