Antifungal and insecticidal activities of rhein derivatives: synthesis, characterization and preliminary structure–activity relationship studies

Abstract

There is an urgent need to replace highly polluting pesticides with environmentally friendly green pesticides of high efficiency and low toxicity, because of the growing concern for quality and safety of agricultural products. To discover new pesticides with diverse chemical structures from natural products, a series of rhein derivatives 3a-9b were designed, synthesized, and evaluated for their antifungal activity and insecticidal activity. The bioassay showed that some compounds exhibited moderate antifungal activity against Rhizoctonia solani, but lower activity against the other five pathogens. Surprisingly, most compounds displayed potent insecticidal activity against Spodoptera litura and Tetranychus cinnabarinus at a concentration of 2 μmol/mL. In particular, compounds 3a, 5a and 3 b exhibited potent insecticidal activities against S. litura at 72 h, with mortality rates of 100%, 100% and 92.1%, respectively, which were equivalent to that of the insecticide fipronil (100%). Their structure-activity relationships were also discussed. The findings of this experiment provide helpful research ideas for the development of these rhein derivatives as novel natural product-based pesticides in crop protection.

Graphical Abstract

Keywords:

• Rhein
• synthesis
• derivatives
• antifungal activity
• insecticidal activity
• structure–activity relationship

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This investigation was supported by the programs of the National Key R&D Program of China (grant no. 2018YFD0200500), the National Natural Science Foundation of China (No. 31672069) and the Funds for Excellent Doctoral Dissertation Cultivation Program in Yangtze University (No. YB2018005).