Streptonaphthyridine A, a new naphthyridine analogue with antiproliferative activity against human glioma cells from mariana trench-associated actinomycete Streptomyces sp. SY2111

Abstract

A new naphthyridine analogue, named streptonaphthyridine A (1), together with eight previously reported compounds (2–9), were isolated from a Mariana Trench sediment-associated actinomycete Streptomyces sp. SY2111. Planar structure of streptonaphthyridine A was established by analyses of its HRESIMS data and extensive NMR spectra and its absolute configuration was determined by a combination of single crystal X-ray diffraction analysis and optical rotation calculations. Streptonaphthyridine A (1) had antiproliferative activity against human glioma U87MG and U251 cells with IC₅₀ values of 7.9 ± 1.3 and 13.4 ± 2.7 µM, respectively, and the known compound monomethylsulochrin (7) showed more potent activity with IC₅₀ values of 0.6 ± 0.1 µM for U87MG cells and 0.1 ± 0.0 µM for U251 cells.

Graphical Abstract

Keywords:

• Mariana Trench actinomycete
• Streptomyces sp. SY2111
• Streptonaphthyridine A
• antiglioma activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the National Key R&D Program of China (No. 2018YFC0310600), the National Natural Science Foundation of China (No. 81773587), and the HPC Center of Zhejiang University (Zhoushan Campus).