Structural elucidation and α‑glucosidase inhibitory activity of a new xanthone glycoside from Lomatogonium rotatum (L.) Fries es Nym

Abstract

A new xanthone glycoside, 1,8-dihydroxyl-2,5-dimethoxy-xanthone-6-O-β-D-glucoside (1), along with two known xanthone glycosides and two flavonoid glycosides were isolated from the aerial parts of Lomatogonium rotatum (L.) Fries es Nym. The structure of 1 was elucidated by analysis of its spectroscopic data, including UV, IR, HR-ESI-MS and extensive 1 D and 2 D NMR techniques. In vitro test, compound 1 behaved similarity to swertianolin against α‑glucosidase and more potent inhibitory effects than the positive control, acarbose.

Graphical Abstract

Keywords:

• Lomatogonium rotatum
• Xanthone glycoside
• Spectroscopic method
• α‑glucosidase inhibitory activity

Acknowledgements

This work was supported by the National Key R&D Program of China (2019YFC1712300), open fund project of Key Laboratory of Mongolian Medicine R & D project of Ministry of Education (MDK2020022) and Inner Mongolia Autonomous Region Natural Science (2021MS08070). Foundation in China.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Key R&D Program of China (2019YFC1712300), open fund project of Key Laboratory of Mongolian Medicine R & D project of Ministry of Education (MDK2020022) and Inner Mongolia Autonomous Region Natural Science (2021MS08070). Foundation in China.