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Abstract
A new paraherquamide named aculeaquamide A (1) was isolated from an EtOAc extract of Aspergillus aculeatinus WHF0198 culture media together with five known compounds. The structures of the isolated compounds were elucidated by analysis of NMR and MS data, and the absolute configurations of compound 1 was confirmed by CD spectroscopic methods. All isolated compounds were evaluated for their cytotoxicity against three human cancer cell lines, Bel-7402, A549, and HCT-116. Compounds 1 and 2 showed cytotoxicity against Bel-7402 with IC50 values of 3.3 and 1.9 μM, respectively.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This work was partially supported by the National Key Research and Development Program of China (No. 2018YFC0311000), the National Natural Science Foundation of China (No. 81973201), the Natural Science Foundation of Hubei Province (No. 2020CFB726), and the Scientific Research Project of Wuhan Municipal Health Commission (No. WX20A14).