Antioxidant effects of diarylheptanoids from two Curcuma species

Abstract

Five linear diarylheptanoids (1-5), including a new one (1), were isolated from the rhizomes of Curcuma kwangsiensis S. G. Lee et C. F. Liang, while four linear diarylheptanoids (6-9) and four cyclic diarylheptanoids (10-13) were isolated from the roots of Curcuma aromatica Salisb. Using the model of H₂O₂-induced PC12 cells, the antioxidant effects of these thirteen diarylheptanoids from these two traditional Chinese medicines from Curcuma genus of Zingiberaceae family were investigated. As result, they produced different efficiency on damaged cell viability, ROS, LDH, SOD, CAT, and GSH-Px, which were the six indexes related to oxidative stress. Further, the correlation between these six bio-indexes and 53 selected molecular descriptors of diarylheptanoids was determined by PLS regression analysis.

Graphical Abstract

Keywords:

• Linear diarylheptanoid
• cyclic diarylheptanoid
• Curcuma kwangsiensis S. G. Lee et C. F. Liang
• Curcuma aromatica Salisb.
• antioxidant effect
• Zingiberaceae

Disclosure statement

No conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by the Natural Science Foundation of China (32060105) and the Applied Basic Research Foundation of Yunnan Province (202101AT070133).