A new megastigmane glycoside, a new organic acid glycoside and other constituents with anticomplementary activity from Artemisia halodendron

Abstract

A new megastigmane glycoside, (1R,5R,6S,7E)-megastigman-3,9-dione-7-en-6,11-diol 11-O-β-D-glucopyranoside (1), and a new organic acid glycoside, methyl (4 R)-4-O-β-D-glucopyranosyl-decanoate (2), together with eight known compounds (3–10), were isolated from the aerial parts of Artemisia halodendron Turcz. ex Bess. (Asteraceae). Their chemical structures were elucidated by 1 D and 2 D NMR and HR-ESI-MS spectra and DP4+ probability analysis. Among the identified compounds, compounds 5, 6 and 10 were isolated from the family Asteraceae, and compounds 3, 4 and 7–9 were identified from the genus Artemisia for the first time. All of the compounds were evaluated for their anticomplementary activity against the classical pathway (CP) and the alternative pathway (AP). Compounds 7 and 9 showed anticomplementary activity with the CH₅₀ values of 0.31 ± 0.08 and 0.50 ± 0.09 mM, respectively.

Graphic Abstract

Keywords:

• Artemisia halodendron
• megastigmane glycoside
• organic acid glycoside
• anticomplementary activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 81760627). This work was also financially supported by the Education Department of Jilin Province (NO. JJKH20220560KJ) and the Doctoral Scientific Research Foundation of Yanbian University (No. 202029).