https://orcid.org/0000-0001-7997-5967
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ABSTACT
A chemical investigation of the endophyte Penicillium sp. Nb 19, isolated from leaves of the traditionally medical plant Baphicacanthus cusia (Nees) Bremek., yielded one new indole diterpenoid, 7-methoxy-13-dehydroxypaxilline (1) together with seven known metabolites (2-8). The obtained structure of compound 1 was elucidated by its spectroscopic data. In addition, the absolute configuration of compound 6 was confirmed by ECD for the first time. Compounds 1-6 were evaluated for antitumor activity against MCF-7, HepG2, and HCCC-9810 cell lines.
GRAPHICAL ABSTRACT
Disclosure statement
The authors declare that there is no conflict of interest in this paper.
Additional information
Funding
The work was supported by The Science and Technology talents and platform plan of Yunnan Province (No. 202105AG070011), Yunnan provincial Science and Technology Major Projects (No. 202102AA100020).