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Abstract
One previously undescribed tricyclo-diterpenoid saponin (1), one undescribed dammarane triterpenoid saponin (2) and four known triterpenoids (3–6) were isolated from the aerial part of Isodon macrocalyx. Their structures were determined using 1 D- and 2 D-NMR, HRESIMS, and comparison of their spectroscopic data with previously reported data. The isolates were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compounds 2 and 3 exhibited moderate anti-HBV activity.
GRAPHICAL ABSTRACT
Disclosure statement
The authors declare no competing financial interest.
Additional information
Funding
One of the authors (JL.) acknowledges the following grants for funding this project: National Natural Science Foundation of China (32060097); The Natural Science Foundation of Guangxi Province (2018GXNSFDA050007).