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Abstract
One cularine-type alkaloid (1) was isolated along with two known compounds (2 and 3) from the roots of Cissampelos pareira. The isolated compound’s chemical structures were elucidated by 1 D and 2 D NMR spectroscopy and mass spectrometry analysis. This is the first report on the cularine-type alkaloid from the genus Cissampelos. Compound (2) was reported for the first time from C. pareira. In silico molecular docking analysis showed various interactions of compounds with the active site residue of GABAA receptor, which could help to understand their putative mode of action in neurodevelopmental malfunctions and in anaesthesia.
Graphical Abstract
Acknowledgment
We are thankful to the Director, CSIR-IHBT, Palampur, for providing the necessary facilities. Ms. Surekha Kumari and Mr. Anmol are grateful to CSIR, New Delhi, and DST-INSPIRE for Senior Research Fellowships, respectively. CSIR-IHBT Communication No. 5106
Disclosure statement
The authors report no conflict of interest.