https://orcid.org/0000-0002-5160-5347
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Abstract
Three new annonaceous acetogenins, annotemoyin L (1), annotemoyin Y (2) and annotemoyin X, (3) were isolated from the seeds of Annona squamosa Linn. Their structures were ascertained by chemical methods and spectral data. The cytotoxic activities of compounds against three multidrug-resistant cancer cell lines were evaluated, and compound 3 exerted strong cytotoxicity against SMMC 7721/ADR (IC50 0.163 μM), A549/T (IC50 0.064 μM) and MCF-7/ADR (IC50 0.057 μM).
Graphical Abstract
Acknowledgements
This work was supported by the National Natural Science Foundation of China (grant number 81573577, 82104355 and 81403082) and China Postdoctoral Science Foundation (2021M701766).
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the National Natural Science Foundation of China (grant number 81573577, 82104355 and 81403082) and China Postdoctoral Science Foundation (2021M701766).