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Abstract
A new clerodane diterpenoid, crotolanin A (1), along with three known clerodane diterpenoids, crotoeurin B (2), teucvidin (3) and teucvin (4), was isolated from the ethanol extract of the leaves and twigs of Croton lachnocarpus Benth. Their structures were identified by extensive NMR spectroscopic and HRESIMS analyses. The dopaminergic neuroprotective activity of compounds 1-4 was tested by using transgenic Caenorhabditis elegans pathological model. Compound 2 alleviated dopaminergic neuron degeneration of worms induced by 6-hydroxydopamine (6-OHDA) that represented a potential therapy for Parkinson’s disease (PD).
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China (No. 31870324 and No. 31670350) and the Natural Science Foundation of Gansu Province, China (No. 21JR7RA477 and No. 21JR7RA444).