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Abstract
A new helvolic acid derivative (1), together with nine known compounds (2-10) were isolated from the metabolites of Aspergillus udagawae MST1-10 with the bioassay-guided fractionation method. Their structures were identified on the basis of spectroscopic analysis. The absolute configuration of compound 1 was elucidated through NOESY and ECD spectra. Compound 2 displayed significant antibacterial activities against Stenotrophomonas maltophilia with MIC value of 2 μg/mL (Trimethoprim, MIC = 64 μg/mL), and with biofilm inhibition rates of 96.41%, 87.77%, and 41.70% at 4MIC, 2MIC, and MIC, respectively.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was financially supported by the National Natural Science Foundation of China (No. 81903496), and Science and Technology Project of Guizhou Province ([2020]1Y394), and Scientific Research Foundation for Innovative Talent of Guizhou Province ([2020]6011), and the Project of Science and Technology Department of Guizhou Province ([2020]5006.