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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 8
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Research Articles

A new polysaccharide from leaves of Sabia parviflora

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Pages 1302-1310 | Received 02 Aug 2022, Accepted 14 Oct 2022, Published online: 28 Oct 2022
 

Abstract

A new polysaccharide (SPT1) was isolated from Sabia parviflora Wall. ex Roxb., and the structure was identified by GPC, 1D and 2D NMR spectroscopy, SEM and AFM. The results showed that the average molecular weight (Mn) of SPT1 was 4.057 × 103 Da, and it was composed of α-glucose with a connection mode of 1→6. The SEM showed that the particle size of SPT1 was 1–200 μm and there were small gaps between the crystals. SPT1 was mainly spherical aggregates in AFM, each aggregate was 0.550–0.983 μm long, 1.059–2.275 μm wide and 208–450 nm high. Furthermore, its liver-protective and PTP1B inhibitory activities were evaluated, and the results showed that SPT1 exhibited moderate effects of liver-protective and PTP1B inhibitory activity. The above results provided experimental evidence for the folk application of S. parviflora in the treatment of hepatitis.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was financially supported by grants from Yichang Medical and Health Research Project (No. A22-2-045), the National Natural Science Foundation of China (No. 81803383), and cooperation project of plant development and management center for soil and water conservation of ministry of water resources (No. SDHZ2019030), and this research was also supported by the 111 Project (D20015).

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