Flavonoid glycosides and ellagic acid cognates from defatted African mango (Irvingia gabonensis) seed kernel

Abstract

Seventeen compounds of diverse classes including four flavonoid glycosides, five ellagic acid derivatives, and eight other metabolites were isolated from the methanolic extract of the defatted seed kernel of Irvingia gabonensis. Among the isolates, quercetin 3-O-methyl-4′-[α-L-rhamnopyranosyl-(1→3)]-O-α-L-rhamnopyranoside (1) and 3,3′-di-O-methyl-4'-O-α-L-rhamnopyranosylellagic acid 4-sulfate ester (5) were found to be previously undescribed. Structure elucidation was mainly achieved by the interpretation of 1D and 2D NMR and HRESIMS spectral data. Though compound 6 was previously reported, its ¹³C NMR data is being reported herein for the first time. To the best of our literature search knowledge, this is the first phytochemical report on I. gabonensis seed kernels.

Graphical Abstract

Keywords:

• Irvingia gabonensis
• Irvingiaceae
• African mango seed kernel
• flavonoid glycosides
• ellagic acid derivatives

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is supported in part by Science-Based Authentication of Botanical Ingredients, funded by the Center for Food Safety and Applied Nutrition, US Food and Drug Administration grant number 5U01FD004246.