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Abstract
Liquidambarines A − C (1−3), three new abietane-type diterpenoids, together with five known compounds (4−8) were isolated from the resin of Liquidambar formosana Hance. Their structures were elucidated by the combination of spectroscopic and computational methods. We explored their anti-inflammatory potential by analyzing the protein expression of iNOS and COX-2. Compounds 1 and 3 exhibit significant anti-inflammatory activities without cytotoxicity. These experimental studies suggest these new abietane-type diterpenoids have the potential to be candidates for inflammation-associated diseases.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This study was supported by the National Key Research and Development Program of China (2017YFA0503900), Shenzhen Fundamental Research Program (JCYJ20200109114003921), National Science Fund for Distinguished Young Scholars (81525026), Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products (2021B1212040015), and SZU Top Ranking Project (827/000327).