Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 8
219
Views
2
CrossRef citations to date
0
Altmetric
Research Articles

Investigation on the chemical constituents of the marine-derived fungus strain Aspergillus brunneoviolaceus MF180246

, , , , & ORCID Icon
Pages 1369-1374 | Received 30 Aug 2022, Accepted 01 Nov 2022, Published online: 11 Nov 2022
 

Abstract

Aspergillus have been proven to be excellent resources for new natural products. During our systematic biodiversifying new compounds from marine derived fungi, one novel compound, asperbrunneo acid (1), along with seven bistetrahydroxanthone analogues, secalonic acid D (2), secalonic acid F (3), secalonic acid F1 (4), secalonic acid H (5), penicillixanthone A (6), chrysoxanthone C (7), and asperdichrome (8), one ketodivinyllactonic steroid, herbarulide (9), as well as one tyrosine-derived compound, aspergillusol A (10), were isolated from the marine-derived fungus Aspergillus brunneoviolaceus MF180246. These structures were elucidated by HRMS, 1 D and 2 D NMR analysis. Compound 1 possessed the first reported new carbon skeleton natural product. Compounds 1, 4, 5, 6, 7 and 8 showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration values of 200, 25, 50, 6.25, 50, and 25 µg/ml, respectively.

Graphic Abstract

Disclosure statement

The authors declare that they have no conflicts of interest.

Additional information

Funding

This work was funded by grants from the National Natural Science Foundation of China (81973204), the Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA (MBSMAT-2019-06), and Research Foundation for Advanced Talents of Beijing Technology and Business University (19008021176).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.