Two new isoquinoline alkaloids from Hypecoum leptocarpum Hook. f. et Thoms

Abstract

Two new isoquinoline alkaloids, hypecocarpinine (1) and leptocaramine (2) along with five known ones including leptopidine (3), corydamine (4), protopine (5), dihydroprotopine (6) and oxohydrastinine (7), were isolated from Hypecoum leptocarpum Hook. f. et Thoms. Structures of the compounds were elucidated using spectroscopic methods, including UV, IR, HR-ESI-MS, 1 D and 2 D NMR. The cytotoxic activities of these compounds were evaluated using MTT assay. The results showed that compounds 2, 4, and 7 have moderate cytotoxicity against human lung cancer (A549) and human gastric carcinoma (MGC-803) cell lines.

Graphical Abstract

Keywords:

• Isoquinoline alkaloid
• Hypecoum leptocarpum Hook. f. et Thoms
• cytotoxic activities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by the Genebank of Qinghai-Tibet Plateau Biota (2021-SF-SW1), the Key R&D Program of Ningxia Hui Autonomous Region (2020BFG03002), and the Qinghai Provincial Key Laboratory of Tibetan Medicine Research (2022-ZJ-Y03).