Phytochemical analysis of Brugmansia suaveolens Bercht. & J. Presl and its therapeutic potential for topical use

Abstract

Brugmansia suaveolens Bercht. & J. Presl represents a promising source of new active molecules. Therefore, the aim of the study is to outline the profile of secondary metabolites and their therapeutic potential and in vitro safety properties. The identification of substances was carried out through the chromatographic profile, while the evaluation of therapeutic use was conducted through in vitro biological assays of antioxidant and antimicrobial activity and quantification of the total phenolic content. The safety of the extracts was evaluated using a cytotoxicity assay. The results found revealed the presence of different secondary metabolites, such as flavonoids and alkaloids. Biological assays showed promising antimicrobial activity in gram-negative strains. Regarding safety, greater cytotoxicity is observed in macrophage cells. The study demonstrated that the extracts are potent for therapeutic use, aiming at the development of a phytoproduct for topical use, providing an innovative, relevant and significant character for future research.

Graphical Abstract

Keywords:

• Brugmansia suaveolens Bercht. & J. Presl
• phytochemical
• anti-inflammatory
• antimicrobial
• therapeutic potential

Acknowledgements

The authors are thankful to the Faculty of Pharmacy of the Federal University of Rio de Janeiro for the support of the Pharmaceutical Technology Institute of Farmanguinhos and the Paulo de Góes Institute of Microbiology.

Authors’ contributions

Cardoso V.S., and Vermelho A.B. guidance and tests conducted. Valverde S.S. contributed to the phytochemical analysis and analytical tools. Schuenck-Rodrigues R.A. and Da Costa. analyzed the data, wrote the manuscript and performed the experiments. Ricci-Júnior E. supervised and supervised the activities. All authors read and approved the manuscript.

Disclosure statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Funding

The author(s) reported there is no funding associated with the work featured in this article.