Synthesis, X-ray structure and anticancer activity evaluation of a binuclear La(III) complex with anthranilic acid

Abstract

A binuclear La(III) complex {[La₂(HA)₄(H₂O)₄(C₂H₅OH)₂Cl₂]Cl₄ (C1)} with 2-aminobenzoic acid (HA) was prepared from the ligand and heptahydrated lanthanum chloride. The complex was characterised by X-ray crystallography that revealed anti-prismatic geometry around both of the lanthanum. In the complex, the four 2-aminobenzoic acid ligands are zwitter ionic and the two lanthanum(III) ions net charge is only counterbalanced by chloride ions. The complex cytotoxicity was determined against human breast (MDA-MB-231), prostate (PC-3) and bladder (T-24) cancer cells. This complex afforded cytotoxicity towards the T-24 bladder cancer cells with an IC₅₀ value of 383.5 µg/mL (319 µM). In contrary, activities by the lanthanum complex with IC₅₀ values of 1124 µg/mL (934 µM) and 739 µg/mL (614 µM) were, respectively, shown against the MDA-MB-231 and PC-3 cancer cells. This means the complex is more cytotoxic against the T-24 cells, despite that its activity is less compared with activities shown by classical drugs.

Graphical Abstract

Keywords:

• 2-Aminobenzoic acid
• rare earth elements
• XRD
• antiproliferation

Acknowledgments

The authors thank RNDr. Ivana Císarová (Charles University, Czech Republic) for her help in collecting the crystallographic data and solving the crystal structure of the complex.

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.