Abstract
A new naphthoquinone derivative (1) together with twenty-three known compounds (2–24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1–13 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 μmol·L−1, respectively.
Author contributions
Conceptualization, Liu S.J. and Luo H.; methodology, Luo H.; software, Fang W.T.; validation, Zhang H., Li Y.; investigation, Fang W.T., Luo. H., Kong Q.H., and Zhang H.; resources, Fang C.W.; writing—original draft preparation, Luo H., Fang W.T.; writing—review and editing, Luo H., Zhang H.; supervision, Fang C.W.; project administration, Liu S.J.; funding acquisition, Liu S.J.
Disclosure statement
No potential conflict of interest was reported by the authors.