Chryroxosides A–E: five new triterpene saponins from the leaves of Chrysophyllum roxburghii G.Don. and their cytotoxic activity

Abstract

Five undescribed oleanane triterpene glycosides named chryroxosides A–D (1–5), together with five known compounds (6–10) were isolated from the leaves of Chrysophyllum roxburghii G.Don. Their chemical structures were elucidated by extensive spectroscopic data analyses including IR, HR-ESI-MS, 1D and 2D NMR). Compounds 1, 3, and 5 showed cytotoxic effects against KB, HepG2, HL60, P388, HT29, and MCF7 cell lines with the IC₅₀ values ranging from 14.40 to 52.63 μM compared to the positive control compound (ellipticine) with the IC₅₀ values ranging from 1.34 to 1.99 μM.

Graphical Abstract

Keywords:

• Chrysophyllum roxburghii
• Sapotaceae
• chryroxoside
• cytotoxic evaluation

Acknowledgments

The authors would like to thank Dr Do Van Hai at the Institute of Ecology and Biological Resources, VAST for the plant identification. The authors would also like to thank NATPROCHEMLAB for the cytotoxic activity screening of Vietnam plants.”

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2018.358.